Fady Hannah-Shmouni, MD, FRCPC, ABIM
GLP-1 and Incretin Therapies
How they work, how to use them, and the law · First edition · 2026
About this monograph
A 311-page first-edition clinical reference on GLP-1 and incretin therapies, from receptor biology and approved medicines to clinical use, emerging agents, and regulation.
The book examines obesity and other indications, dose-response evidence, discontinuation, switching, adverse effects, monitoring, and contraindications. It also covers retatrutide, the development pipeline, compounding, gray-market products, global access, pricing, and generics.
Educational content for licensed clinicians. It is not individual medical advice, a prescribing protocol, or a recommendation for unapproved use. Readers should verify current labeling and regulatory requirements.
What you'll learn
- GLP-1, GIP, and glucagon biology and the pharmacology of approved incretin medicines
- Evidence for obesity and other indications, with limitations and clinical context
- Discontinuation, weight regain, switching, adverse effects, and monitoring
- Retatrutide and other agents in the development pipeline
- Compounding, gray-market products, enforcement, global access, and generics
Who it's for
- Licensed physicians, nurse practitioners, physician associates, and pharmacists
- Researchers and clinical educators reviewing incretin therapy evidence
What's inside
- 1Foundations: GLP-1, GIP and glucagon; history and development; pharmacology
- 2Clinical use: obesity and other indications; dose-response; microdosing
- 3Discontinuation, mortality, weight regain and switching
- 4Adverse effects, monitoring and contraindications
- 5The brain, cancer risk and cancer care
- 6Agents and pipeline: retatrutide and future therapies
- 7Regulation and practice: compounding, enforcement and litigation
- 8Global access, pricing and generics
- 9Appendix A: supplements and endogenous GLP-1
- 10Appendix B: clinical matrix and trial glossary
Preview
Free sampleThis is a free preview. Purchase the book above to download the full PDF.
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